Chronic obstructive pulmonary disease (COPD) is now considered a systemic inflammatory disease. While the primary symptoms (cough, breathlessness, sputum) and decline in pulmonary function are the primary considerations for treatment of patients with COPD, this disease is also associated with increased frequency of disease involving other organ systems (e.g., cardiovascular disease, anaemia, osteoporosis, diabetes). The slides in this module consider COPD comorbidities and the mechanisms that may underlie them.